![road of the dead 2 alpha mutant road of the dead 2 alpha mutant](https://ars.els-cdn.com/content/image/1-s2.0-S1097276520302343-fx1.jpg)
A recent study reported on a cluster of cases in Manaus, the largest city in the Amazon region, in which the P.1 variant was identified in 42% of the specimens sequenced from late December.There is evidence to suggest that some of the mutations in the P.1 variant may affect its transmissibility and antigenic profile, which may affect the ability of antibodies generated through a previous natural infection or through vaccination to recognize and neutralize the virus.The P.1 lineage contains three mutations in the spike protein receptor binding domain: K417T, E484K, and N501Y.The P.1 variant is a branch off the B.1.1.28 lineage that was first reported by the National Institute of Infectious Diseases (NIID) in Japan in four travelers from Brazil, sampled during routine screening at Haneda airport outside Tokyo.There is some evidence to indicate that one of the spike protein mutations, E484K, may affect neutralization by some polyclonal and monoclonal antibodies.Currently there is no evidence to suggest that this variant has any impact on disease severity.The variant also was identified in Zambia in late December 2020, at which time it appeared to be the predominant variant in the country.This variant was first identified in Nelson Mandela Bay, South Africa, in samples dating back to the beginning of October 2020, and cases have since been detected outside of South Africa, including the United States.Unlike the B.1.1.7 lineage detected in the UK, this variant does not contain the deletion at 69/70. This variant has multiple mutations in the spike protein, including K417N, E484K, N501Y.Early reports found no evidence to suggest that the variant has any impact on the severity of disease or vaccine efficacy.In January 2021, scientists from UK reported evidence that suggests the B.1.1.7 variant may be associated with an increased risk of death compared with other variants.This variant is associated with increased transmissibility (i.e., more efficient and rapid transmission).
![road of the dead 2 alpha mutant road of the dead 2 alpha mutant](https://post.healthline.com/wp-content/uploads/2021/11/austria-police-732x549-thumbnail-732x549.jpg)
![road of the dead 2 alpha mutant road of the dead 2 alpha mutant](https://i.gr-assets.com/images/S/compressed.photo.goodreads.com/books/1554329715l/42060069.jpg)
This variant was detected in the US at the end of January 2021. This variant has 17 unique mutations, including three in the receptor binding domain of the spike protein. In Brazil, a variant of SARS-CoV-2 (known as P.1) emerged that was first was identified in four travelers from Brazil, who were tested during routine screening at Haneda airport outside Tokyo, Japan.This variant was reported in the US at the end of January 2021. Cases attributed to this variant have been detected in multiple countries outside of South Africa. This variant shares some mutations with B.1.1.7. In South Africa, another variant of SARS-CoV-2 (known as 20H/501Y.V2 or B.1.351) emerged independently of B.1.1.7.This variant was reported in the US at the end of December 2020. More studies are needed to confirm this finding. In January 2021, scientists from UK reported evidence that suggests the B.1.1.7 variant may be associated with an increased risk of death compared with other variants. This variant has since been detected in numerous countries around the world, including the United States (US). In the United Kingdom (UK), a new variant of SARS-CoV-2 (known as 20I/501Y.V1, VOC 202012/01, or B.1.1.7) emerged with a large number of mutations.Several new variants emerged in the fall of 2020, most notably: Multiple SARS-CoV-2 variants are circulating globally.